Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPβ factors.

Authors: Giorgia D Ugarte, Emilio Diaz, Miguel Biscaia, Jimmy Stehberg, Martin Montecino, Brigitte van Zundert

Journal, date & volume: J. Cell. Physiol., 2013 Apr , 228, 860-70

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23018770

Abstract
Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls the expression of several sensory nociceptive receptors, including TRPV1. Here, we show that Runx1 up-regulates TRPV1 transcription activity by interacting directly with the proximal TRPV1 gene promoter sequence. Importantly, C/EBPβ a well-established heterodimer partner of Runx1 also binds to the TRPV1 promoter and cooperates with Runx1 to further stimulate TRPV1 transcription. Our results support a mechanism where Runx1-C/EBPβ-containing transcription regulatory complexes are recruited to the TRPV1 gene promoter to modulate TRPV1 expression in dorsal root ganglia neurons.