Referenced in: none

Automatically associated channels: Slo1

Title: Different effects of α- and γ-glycine on the aberrant activity of pyramidal neurons of hippocampal slices.

Authors: I A Malakhin, A F Achkasov, A S Ratushnyak, T A Zapara, A L Markel, E V Boldyreva, V V Boldyrev

Journal, date & volume: Dokl. Biol. Sci., 2012 May-Jun , 444, 157-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22760614

Abstract
Experiments in vitro on hippocampal slices of mouse have shown that solutions prepared from polymorphic modifications α- and γ-glycine have different effect on the aberrant activity of neurons. In the presence of α-glycine the excitability of these neurons decreased more slowly, prolonging its modulating effect on NMDA type glutamate receptors. This effect agrees with higher biological activity of α-polymorphic modifications (as compared with that of the α-form) that previously observed with respect to behavior of mice from the line with genetic diathesis to catalepsy, which were used as a biological model for investigation of some pathological behavior forms.