Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Interaction of Hypoxia and Core Temperature: Potential Role of TRPV1.

Authors: Nathaniel Y W Yuen, Sandra G Vincent, Brian Foo, John T Fisher

Journal, date & volume: Adv. Exp. Med. Biol., 2012 , 758, 173-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23080159

Abstract
Hypoxia exposure in small mammals elicits an initial rise in ventilation followed by a reduction to levels that are often less than the normoxic value. The fall in ventilation is matched by a decrease in metabolism rate and a reduction in core body temperature (Tb). The transient receptor potential vanilloid 1 (TRPV1) ion channel has been implicated in thermoregulation (Caterina et al., Science 288:306-313, 2000) and recently shown to exert a tonic effect on Tb in human subjects (Gavva et al., Pain 136:202-210, 2008). We review herein the hypothesis that TRPV1 modulates the Tb response to hypoxia. We provide preliminary evidence that a 24 h hypoxia (FIO(2)=0.1) exposure caused an enhanced decrease in Tb in mutant TRPV1(-/-) mice compared to the TRPV1(+/+) genotype (Tb was » 1°C lower than TRPV1(+/+)). Further investigation is warranted to determine the extent of TRPV1 ion channel involvement in acute and adaptive responses to hypoxia.