Referenced in: none

Automatically associated channels: TRP

Title: TRP channels: diagnostic markers and therapeutic targets for breast cancer?

Authors: Halima Ouadid-Ahidouch, Isabelle Dhennin-Duthille, Mathieu Gautier, Henri Sevestre, Ahmed Ahidouch

Journal, date & volume: Trends Mol Med, 2012 Dec 16 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23253476

Abstract
Breast cancer is the most frequently occurring cancer in women and has the highest rate of mortality. Ion channels such as the transient receptor potential (TRP) channels could play a critical role in the development and progression of cancer. Although these channels are frequently and abundantly expressed in many tumors, their expression, activity, and roles in the context of breast cancer remain poorly understood. This review summarizes our current knowledge regarding TRP channels expressed in human breast tissue, primary human breast epithelial cells, and cell lines, the functional role of TRP channels during breast cancer cell growth and migration, as well as their relationship with clinical and pathological features.