Referenced in: none

Automatically associated channels: Kv11.1

Title: Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications.

Authors: John P McCauley, Cathy L Dantzman, Megan M King, Glen E Ernst, Xia Wang, Kelly Brush, William E Palmer, William Frietze, Donald W Andisik, Valerie Hoesch, Kenneth Doring, James Hulsizer, Khanh H Bui, Jay Liu, Thomas J Hudzik, Steven S Wesolowski

Journal, date & volume: Bioorg. Med. Chem. Lett., 2012 Jan 15 , 22, 1169-73

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22197139

Abstract
A novel series of piperazine derivatives exhibits sub-nanomolar binding and enhanced subtype selectivity as δ-opioid agonists. The synthesis and SAR are described as well as the application of computational models to improve in vitro ADME and safety properties suitable for CNS indications, specifically microsomal clearance, permeability, and hERG channel inhibition.