Referenced in: none

Automatically associated channels: Slo1

Title: [The effects of pH0 on electrophysiological properties of VSMCs in brain artery of spontaneously hypertensive rats].

Authors: Yuan-yuan Shang, Jun-qiang Si, Li Li, Yu Lian, Ke-tao Ma

Journal, date & volume: Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2012 May , 28, 268-70

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22860433

Abstract
To investigate the effects of pH0 on the electrophysiological properties of vascular smooth muscle cells (VSMCs) in brain artery of spontaneously hypertension rats (SHR).We studied the effects and the ion mechanism of pH0 on whole-cell membrane current of VSMCs in brain artery of 200 - 250 g SHR by whole-cell patch clamp recordings.1. Acidic pH0 could inhibit the outward current of VSMCs of brain artery in SHR in a voltage-dependent manner. It induced a more pronounced inhibition of the outward current from 0 to + 60mV; 2. In the presence of 1 mmol/L TEA, the inhibition of acidic pH0 on the outward current of VSMCs of brain artery was inhibited.The changes of outward current of VSMCs of brain artery in SHR induced by pH0 may be connected with BKCa channel.