Referenced in: none

Automatically associated channels: Slo1

Title: A quantitative model of human jejunal smooth muscle cell electrophysiology.

Authors: Yong Cheng Poh, Alberto Corrias, Nicholas Cheng, Martin Lindsay Buist

Journal, date & volume: PLoS ONE, 2012 , 7, e42385

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22912702

Abstract
Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.