Referenced in: none

Automatically associated channels: TRP

Title: Antinociception of β-D-glucan from Pleurotus pulmonarius is possibly related to protein kinase C inhibition.

Authors: Cristiane Hatsuko Baggio, Cristina Setim Freitas, Rodrigo Marcon, Maria Fernanda de Paula Werner, Giles Alexander Rae, Fhernanda Ribeiro Smiderle, Guilherme Lanzi Sassaki, Marcello Iacomini, Maria Consuelo Andrade Marques, Adair Roberto Soares Santos

Journal, date & volume: Int. J. Biol. Macromol., 2012 Apr 1 , 50, 872-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22085751

Abstract
β-D-Glucan, a polysaccharide isolated from an edible mushroom Pleurotus pulmonarius (Fr.) Quel., presented antinociceptive activity in mice. This study evaluated the involvement of transient receptor potential (TRP) channels and protein kinase C (PKC) on antinociceptive effect of a (1→3),(1→6)-linked β-D-glucan (GL) in mice. Intraperitoneal administration of GL potently inhibited nociceptive responses induced by intraplantar injections of capsaicin, cinnamaldehyde, menthol, acidified saline and phorbol myristate acetate (PMA). Moreover, Western blot analysis revealed that GL treatment also prevented PMA-induced PKCɛ activation. Collectively, present results demonstrate that GL could constitute an attractive molecule of interest for the development of new analgesic drugs.