Referenced in: none

Automatically associated channels: TRP

Title: [Molecular mechanisms of TRP channels in mechano-sensory transduction].

Authors: Wen-juan Zou, Gui-fang Huang, Li-jun Kang

Journal, date & volume: Zhejiang Da Xue Xue Bao Yi Xue Ban, 2012 Mar , 41, 222-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22499524

Abstract
Channels from the TRP superfamily have essential roles in a wide variety of sensory transductions, especially in mechano-sensation, such as hearing, touch and mechanical pain. TRP channels are also implicated in major channelopathies, including deafness, chronic pain, autosomal dominant polycystic kidney disease (ADPKD) and ventricular hypertrophy. As the leading candidates for mechano-sensitive channels, some TRP channels appear to be mechano-receptor, which can be activated by mechanical forces directly, such as C. elegans TRPN homolog TRP-4; whereas others may act as signal modulators, receiving and amplifying signals indirectly. This review is to introduce the function of TRPs in mechano-sensory transduction and to discuss the underlying molecular mechanisms.