Referenced in: none

Automatically associated channels: TRP

Title: Ion channels and transporters in lymphocyte function and immunity.

Authors: Stefan Feske, Edward Y Skolnik, Murali Prakriya

Journal, date & volume: Nat. Rev. Immunol., 2012 Jul , 12, 532-47

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22699833

Abstract
Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations of diverse cations, such as calcium, magnesium and zinc ions, which function as second messengers to regulate crucial lymphocyte effector functions, including cytokine production, differentiation and cytotoxicity. The repertoire of ion-conducting proteins includes calcium release-activated calcium (CRAC) channels, P2X receptors, transient receptor potential (TRP) channels, potassium channels, chloride channels and magnesium and zinc transporters. This Review discusses the roles of ion conduction pathways in lymphocyte function and immunity.