Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Disease-related changes in TRPV1 expression and its implications for drug development.

Authors: Louis S Premkumar, Mahendra Bishnoi

Journal, date & volume: Curr Top Med Chem, 2011 , 11, 2192-209

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21671875

Abstract
The transient receptor potential vanilloid 1 (TRPV1) channel has been a topic of great interest, since its discovery in 1997. It is a homotetrameric non-selective cation channel predominantly expressed in a population of sensory neurons and its involvement in different modalities of pain has been extensively studied. However, TRPV1 has also been shown to be expressed in non-sensory neurons and non-neuronal cells. TRPV1 is considered as a potential target for drug development, based on its tissue distribution and its role in physiological functions. Here, we summarize the evidences for disease-related alterations in TRPV1 expression and function and review the current perspectives for the therapeutic potential of TRPV1 agonists and antagonists in the treatment of a wide range of diseases.