Channelpedia

PubMed 22605770


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv10.1



Title: Evolutionary diversity of the mitochondrial calcium uniporter.

Authors: Alexander G Bick, Sarah E Calvo, Vamsi K Mootha

Journal, date & volume: Science, 2012 May 18 , 336, 886

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22605770


Abstract
Calcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life, but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria.