Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: [Research progress in the relationship between TRPV1 and visceral hypersensitivity in functional gastrointestinal diseases].

Authors: Shu Li, Li-ping Duan

Journal, date & volume: Beijing Da Xue Xue Bao, 2011 Apr 18 , 43, 311-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21503132

Abstract
Transient receptor potential vanilloid 1(TRPV1) is a nonselective cation channel with high permeability for Ca(2+). It may play a role in the development and maintenance of visceral pain and hypersensitivity states, which has generated a major interest in the development of specific vanilloid antagonists. In this review, a summary of the contribution of TRPV1 in the development of visceral hypersensitivity in functional dyspepsia and irritable bowel syndrome is presented with the structure, location, and related molecular mechanisms.