Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Quantifying and Modeling the Temperature-Dependent Gating of TRP Channels.

Authors: Thomas Voets

Journal, date & volume: , 2012 Feb 2 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22298025

Abstract
The ability to sense environmental temperatures and to avoid noxious heat or cold is crucial for the survival of all organisms. In mammals, sensory neurons from dorsal root and trigeminal ganglia convey thermal information from the skin, mouth and nose to the central nervous system. Recent evidence has established that thermo TRPs, a subset of the TRP superfamily of cation channels, act as primary temperature sensors in cold-and-heat-sensitive neurons. The gating of these thermoTRPs exhibit strong temperature dependence, leading to steep changes in inward current upon heating or cooling. The origin of this striking temperature sensitivity remains incompletely understood. In this review, I propose criteria that define a thermoTRP, analyse the usefulness and limitations of the commonly used parameters thermal threshold and Q(10), provide an overview of possible thermodynamic principles and gating schemes for thermosensitive TRP channels, and perform a meta-analysis of publlished work on the molecular basis of heat sensitivity in TRPV1. This review may form a useful reference for the analysis and interpretation of further biophysical and structure-function studies dissecting the molecular basis of thermosensitivity in TRP channels.