Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy.

Authors: Cadie L Buckley, Alexander J Stokes

Journal, date & volume: Channels (Austin), 2011 Jul-Aug , 5, 367-74

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21814047

Abstract
TRPV1 (transient receptor potential cation channel, subfamily V, member 1) is best studied in peripheral sensory neurons as a pain receptor; however TRPV1 is expressed in numerous tissues and cell types including those of the cardiovascular system. TRPV1 expression is upregulated in the hypertrophic heart, and the channel is positioned to receive stimulatory signals in the hypertrophic heart. We hypothesized that TRPV1 has a role in regulating cardiac hypertrophy. Using transverse aortic constriction to model pressure overload cardiac hypertrophy we show that mice lacking functional TRPV1, compared to wild type, have improved heart function, and reduced hypertrophic, fibrotic and apoptotic markers. This suggests that TRPV1 plays a role in the progression of cardiac hypertrophy, and presents a possible therapeutic target for the treatment of cardiac hypertrophy and heart failure.