Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Lack of transient receptor potential vanilloid-1 enhances Th2-biased immune response of the airways in mice receiving intranasal, but not intraperitoneal, sensitization.

Authors: Tetsuya Mori, Katsuyo Saito, Yasushi Ohki, Hirokazu Arakawa, Makoto Tominaga, Kenichi Tokuyama

Journal, date & volume: Int. Arch. Allergy Immunol., 2011 , 156, 305-12

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21720176

Abstract
Transient receptor potential vanilloid-1 (TRPV1) may modulate allergic airway inflammation because it is expressed not only on the nerve endings but also on several cells of the immune system. We wanted to know the characteristics of airway and systemic responses against sensitization and challenge with allergens in TRPV1 receptor gene knockout mice (TRPV1(-/-)).TRPV1(-/-) and their wild-type counterparts (TRPV1(+/+)) were sensitized with either house dust mite (HDM) or ovalbumin (OVA) via intranasal (i.n.) or intraperitoneal (i.p.) route before the final i.n. challenge with the corresponding allergen. One day after the final challenge, serum IgE levels, cytokine levels in the bronchoalveolar lavage fluid (BALF), and the number of BALF cells were examined after measuring bronchial hyperresponsiveness against methacholine.Compared to TRPV1(+/+), TRPV1(-/-) showed enhanced Th2-biased response after i.n. HDM or OVA sensitization, including increased levels of serum IgE, interleukin 4 (IL-4) and eosinophils in the BALF. By contrast, when sensitized via i.p. route, the response against OVA or HDM was almost similar between TRPV1(+/+) and TRPV1(-/-).TRPV1 receptor may downregulate Th2-biased immune response when sensitized via airways, although this was not the case when sensitized systemically.