Referenced in: none

Automatically associated channels: Kv11.1

Title: Bioactive sulfoximines: syntheses and properties of Vioxx analogs.

Authors: Seong Jun Park, Helmut Buschmann, Carsten Bolm

Journal, date & volume: Bioorg. Med. Chem. Lett., 2011 Aug 15 , 21, 4888-90

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21752640

Abstract
The syntheses and biological profiles of sulfoximine-based Vioxx analogs 2 are described. Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (1).