Referenced in: none

Automatically associated channels: Cav3.2

Title: Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.

Authors: Fabrizio Giordanetto, Laurent Knerr, Nidhal Selmi, Antonio Llinàs, Anders Lindqvist, Qing-Dong Wang, Pernilla Ståhlberg, Fredrik Thorstensson, Victoria Ullah, Kristina Nilsson, Gavin O'Mahony, Got Högberg, Emma Lindhardt, Annika Strand, Göran Duker

Journal, date & volume: Bioorg. Med. Chem. Lett., 2011 Sep 15 , 21, 5557-61

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21782423

Abstract
Chemical evolution of a HTS-based fragment hit resulted in the identification of N-(1-adamantyl)-2-[4-(2-tetrahydropyran-4-ylethyl)piperazin-1-yl]acetamide, a novel, selective T-type calcium channel (Ca(v)3.2) inhibitor with in vivo antihypertensive effect in rats.