Referenced in: none

Automatically associated channels: Kv11.1

Title: Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.

Authors: Xuqing Zhang, Heather Hufnagel, Thomas Markotan, James Lanter, Chaozhong Cai, Cuifen Hou, Monica Singer, Evan Opas, Sandra McKenney, Carl Crysler, Dana Johnson, Zhihua Sui

Journal, date & volume: Bioorg. Med. Chem. Lett., 2011 Sep 15 , 21, 5577-82

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21783361

Abstract
A series of 4-azetidinyl-1-aryl-cyclohexanes as potent CCR2 antagonists with high selectivity over activity for the hERG potassium channel is discovered through divergent SARs of CCR2 and hERG.