Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM7

Title: Transient receptor potential ion channel TRPM7 is required for preventing replicative senescence in pancreatic adenocarcinoma cells.

Authors: Nelson S Yee, Weiqiang Zhou, Minsun Lee

Journal, date & volume: , 2011 Dec 10 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22166235

Abstract
The transient receptor potential TRPM7 ion channel is required for cellular proliferation in pancreatic epithelia and adenocarcinoma. To elucidate the mechanism that mediates the function of TRPM7, we examined its role in survival of pancreatic cancer cells. RNA interference-mediated silencing of TRPM7 did not induce apoptotic cell death. TRPM7-deficient cells underwent replicative senescence with up-regulation of p16(CDKN2A) and WRN mRNA. The combination of anti-TRPM7 siRNA and gemcitabine produced enhanced cytotoxicity as compared to gemcitabine alone. Thus, TRPM7 is required for preventing senescence, and modulation of TRPM7 expression may help improve treatment response of pancreatic cancer by combining with apoptosis-inducing agents.