Referenced in: HCN1

Automatically associated channels: HCN1

Title: The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells.

Authors: Matthew F Nolan, Gaël Malleret, Ka Hung Lee, Emma Gibbs, Joshua T Dudman, Bina Santoro, Deqi Yin, Richard F Thompson, Steven A Siegelbaum, Eric R Kandel, Alexei Morozov

Journal, date & volume: Cell, 2003 Nov 26 , 115, 551-64

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/14651847

Abstract
In contrast to our increasingly detailed understanding of how synaptic plasticity provides a cellular substrate for learning and memory, it is less clear how a neuron's voltage-gated ion channels interact with plastic changes in synaptic strength to influence behavior. We find, using generalized and regional knockout mice, that deletion of the HCN1 channel causes profound motor learning and memory deficits in swimming and rotarod tasks. In cerebellar Purkinje cells, which are a key component of the cerebellar circuit for learning of correctly timed movements, HCN1 mediates an inward current that stabilizes the integrative properties of Purkinje cells and ensures that their input-output function is independent of the previous history of their activity. We suggest that this nonsynaptic integrative function of HCN1 is required for accurate decoding of input patterns and thereby enables synaptic plasticity to appropriately influence the performance of motor activity.