Referenced in: none

Automatically associated channels: Kir2.3

Title: [The correlation between the expression of AQP1 and angiogenesis ability in nasopharyngeal carcinoma].

Authors: Qi Li, Wei Zhang, Bao Zhang

Journal, date & volume: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2010 Dec , 24, 1115-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21395179

Abstract
To investigate the expression and correlation of Aquaporin-1 (AQP1), VEGF and MVD in nasopharyngeal tumor and non-tumor tissues.Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative PCR (RT-PCR) to detect the expression level of AQP1 and VEGF in tissues. MVD were then calculated.Both immunohistochemistry and RT-PCR showed higher expression of AQP1 and VEGF in tumor tissues than in non-tumor tissues. The two factors were positively correlated.In nasopharyngeal carcinoma, AQP1 may participate in angiogenesis by VEGF. Thus it may facilitate the tumor's growing and metastasis.