Referenced in: none

Automatically associated channels: Slo1

Title: [Systematic analysis of molecular mechanisms of action of omega-3 polyunsaturated fatty acids on arrhythmia].

Authors: I Iu Torshin, O A Gromova, E Iu Egorova, K V Rudakov

Journal, date & volume: Kardiologiia, 2011 , 51, 37-49

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21649594

Abstract
Safe pharmacotherapy and prevention of arrhythmia is an urgent problem of modern cardiology. Essential micronutrients such as omega-3 polyunsaturated fatty acids (-3 PUF-) significantly contribute to the metabolic processes in cardiomyocytes and cardiac conduction system. This article presents a systematic analysis of anti-arrhythmic effects of omega-3 PUFA and of standardized ethyl esters of omega-3 PUFA. The currently available data indicate two fundamentally different molecular mechanisms of anti-arrhythmic effects: "slow" and "fast" types. Formulation of fundamental prospects of bioinformatic studies of molecular effects of anti-arrhythmic action of omega-3 PUF-s is presented.