Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: [Changes the TRPV1-immunoreactive neurons of the rat spinal nerve sensory ganglia induced by capsaicin].

Authors: V V Porseva, V V Shilkin, M B Korzina, A A Korobkin, P M Masliukov

Journal, date & volume: Morfologiia, 2011 , 139, 41-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21954707

Abstract
Morphological features of the TRPV1-immunoreactive neurons were studied in thoracic spinal nerve sensory ganglion in 10-, 20-, 30-, 60- and 90-day-old rats under normal conditions and after chemical deafferentation caused by capsaicin (100 mg/kg) subcutaneous injection at postnatal day 2. TRPV1-immunoreactive neurons differed in their morphometric characteristics: positive neurons had very small and small sizes, negative cells had the small, medium and large sizes. Capsaicin treatment of newborn rats was shown to change age dynamics of TRPV1-positive neurons resulting in the reduction of the average cell cross-sectional area and cell numbers during the whole period of observation.