Channelpedia

PubMed 21340152


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir1.1 , Kir2.3 , Kir6.2



Title: Long-term response to sulfonylurea in a patient with diabetes due to mutation in the KCNJ11 gene.

Authors: Marcio F Vendramini, Lucimary C Gurgel, Regina S Moisés

Journal, date & volume: Arq Bras Endocrinol Metabol, 2010 Nov , 54, 682-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21340152


Abstract
To report the long-term (30-month) effect of the switch from insulin to sulfonylurea in a patient carrying the p.G53D (c.158G>A) mutation in KCNJ11 gene.A 29-year-old male patient was diagnosed with diabetes in the third month of life and after identification of a heterozygous p.G53D mutation in the KCNJ11 gene, the therapy was switched from insulin to sulfonylurea.Long-term follow-up (30 months) showed that good metabolic control was maintained (HbA1c: 6.6%) and the glibenclamide dose could be reduced.Long-term therapy with sulfonylureas in patients with neonatal diabetes due to mutation in the KCNJ11 gene is safe and promotes sustained improvement of glycemic control.