Referenced in: none

Automatically associated channels: TRP

Title: Ion channels as targets for cancer therapy.

Authors: Minghua Li, Zhi-Gang Xiong

Journal, date & volume: Int J Physiol Pathophysiol Pharmacol, 2011 , 3, 156-66

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21760973

Abstract
Cancer is a leading cause of death in the world. Conventional treatments have severe side effects and low survival rate. It is important to discover new targets and therapeutic strategies to improve the clinical outcomes of cancer patients. Ion channels are specialized membrane proteins that play important roles in various physiological processes. Recent studies have shown that abnormal expression and/or activity of a number of ion channels e.g. voltage-gated K(+), Na(+), Ca(2+) channels, TRP channels, and epithelial Na(+)/degenerin family of ion channels, are involved in the growth/proliferation, migration and/or invasion of cancer cells. In this review, we summarize the present knowledge about the roles of different ion channels in the development of cancer.