Referenced in: none

Automatically associated channels: Kv11.1

Title: Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline.

Authors: Richard Ducray, Clifford D Jones, Frédéric H Jung, Iain Simpson, Jon Curwen, Martin Pass

Journal, date & volume: , 2011 Jun 25 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21764307

Abstract
Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the properties of this series. The structure-activity relationships against IGF-1R kinase activity as well as inhibition of the hERG ion channel are discussed.