Referenced in: none

Automatically associated channels: TRP , TRPM , TRPML , TRPML3

Title: Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice.

Authors: Simone Jörs, Christian Grimm, Lars Becker, Stefan Heller

Journal, date & volume: PLoS ONE, 2010 , 5, e14317

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21179200

Abstract
TRPML3, a member of the transient receptor potential (TRP) family, is an inwardly rectifying, non-selective Ca2+-permeable cation channel that is regulated by extracytosolic Na+ and H+ and can be activated by a variety of small molecules. The severe auditory and vestibular phenotype of the TRPML3(A419P) varitint-waddler mutation made this protein particularly interesting for inner ear biology. To elucidate the physiological role of murine TRPML3, we conditionally inactivated Trpml3 in mice. Surprisingly, lack of functional TRPML3 did not lead to circling behavior, balance impairment or hearing loss.