Referenced in: none

Automatically associated channels: TRP

Title: Structural biology of TRP channels.

Authors: Minghui Li, Yong Yu, Jian Yang

Journal, date & volume: Adv. Exp. Med. Biol., 2011 , 704, 1-23

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21290287

Abstract
Structural studies on TRP channels, while limited, are poised for a quickened pace and rapid expansion. As of yet, no high-resolution structure of a full length TRP channel exists, but low-resolution electron cryomicroscopy structures have been obtained for 4 TRP channels, and high-resolution NMR and X-ray crystal structures have been obtained for the cytoplasmic domains, including an atypical protein kinase domain, ankyrin repeats, coiled coil domains and a Ca(2+)-binding domain, of 6 TRP channels. These structures enhance our understanding of TRP channel assembly and regulation. Continued technical advances in structural approaches promise a bright outlook for TRP channel structural biology.