Referenced in: none

Automatically associated channels: Slo1

Title: [Acute effects of IL-1β on sodium current in cortical neurons of rats.]

Authors: Cui Qi, Wei-Wei Zhang, Fei Wang, Chao-Fei Bao, Xin-Wei Wang, Xiao-nan Li, Xiao-Qing Yu, Chen Zhou

Journal, date & volume: , 2011 Jun 22 , 32, 323-328

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21698800

Abstract
Interleukin-1β (IL-1β) is an important proinflammatory cytokine that plays a key role in injuries and diseases of the central nervous system (CNS). The voltage-gated Na(+) channel is the most important ion channel of neurons, and is essential for regenerative action potential (AP). The Na(+) channel also contributes to many diseases of the brain. However, relations between IL-1β and central Na(+) channels remain unreported. In this study, whole cell patch-clamp recording was used to investigate the acute effects of IL-1β (10 ng/mL) on voltage-dependent Na(+) currents and AP of cultured cortical neurons from rats. Results showed that the half-activation voltage of Na(+) channels and the threshold of AP, but not the amplitude, slope factor of activation, and inactivation properties, were affected by IL-1β. These data suggest that increased IL-1β in injury and disease may upregulate the excitability of neurons, and thereby exacerbate neurotoxicity.