Referenced in: none

Automatically associated channels: TRP

Title: Heteromerization of TRP channel subunits: extending functional diversity.

Authors: Wei Cheng, Changsen Sun, Jie Zheng

Journal, date & volume: Protein Cell, 2010 Sep , 1, 802-10

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21203922

Abstract
Transient receptor potential (TRP) channels are widely found throughout the animal kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical stimuli, they play crucial physiological roles ranging from sensory transduction to cell cycle modulation. TRP channels are tetrameric protein complexes. While most TRP subunits can form functional homomeric channels, heteromerization of TRP channel subunits of either the same subfamily or different subfamilies has been widely observed. Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts, indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions.