Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM7

Title: Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury.

Authors: Ming-Hua Li, Koichi Inoue, Hong-Fang Si, Zhi-Gang Xiong

Journal, date & volume: , 2011 May 9 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21552295

Abstract
Brain ischemia is a leading cause of death and long-term disabilities worldwide. Unfortunately, current treatment is limited to thrombolysis, which has limited success and a potential side effect of intracerebral hemorrhage. Searching for new cell injury mechanisms and therapeutic interventions has become a major challenge in the field. It has been recognized for many years that intracellular Ca(2+) overload in neurons is essential for neuronal injury associated with brain ischemia. However, the exact pathway(s) underlying the toxic Ca(2+) loading remained elusive. This review discusses the role of two Ca(2+)-permeable cation channels, TRPM7 and acid-sensing channels, in glutamate-independent Ca(2+) toxicity associated with brain ischemia.