Channelpedia

PubMed 21234426


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: BK



Title: Adaptation to short-term stress exposures prevents poststress dysfunction of calcium-activated potassium channels in coronary vessels.

Authors: A P Solodkov, S S Maĭorova, S S Lazuko

Journal, date & volume: Bull. Exp. Biol. Med., 2010 Oct , 149, 391-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21234426


Abstract
Adaptation to short-term stress exposures prevents immobilization stress-induced decrease in functional activity of BK(Ca)channels in smooth muscle cells of coronary vessels developing against the background of NO overproduction and increase in the relative content of oxidized glutathione (change in redox state of the glutathione system). The protective antistress mechanisms of adaptation probably include prevention of NO overproduction by inducible NO synthase and maintenance of dependent glutathione redox state functional activity of BK(Ca)channels in smooth muscle cells of coronary vessels.