PubMed 21059368

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir2.3 , TRP , TRPC , TRPC6

Title: Evidence for a supportive role of classical transient receptor potential 6 (TRPC6) in the exploration behavior of mice.

Authors: Daniel Beis, Rainer K W Schwarting, Alexander Dietrich

Journal, date & volume: Physiol. Behav., 2011 Feb 1 , 102, 245-50

PubMed link:

Non-selective classical transient receptor potential (TRPC) cation channels share important roles in processes of neuronal development and function. To test the influence of TRPC6 activity on behavior, we developed a TRPC6-deficient (TRPC6(-/-)) mouse model in a BALB/c genetic background. Both, TRPC6(-/-) and wild-type (WT) mice were analyzed first for their general health and reflex status (modified SHIRPA protocol) and then in three different behavioral tests (marble-burying test, square open field and elevated star maze). No abnormalities were detected in the SHIRPA protocol. Most interestingly, TRPC6(-/-) mice showed no significant differences in anxiety in a marble-burying test, but demonstrated reduced exploration in the square open field and the elevated star maze. Therefore, TRPC6 channel activity may play a yet unknown role for exploration behavior.