Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Expression of transient receptor potential vanilloid-1 (TRPV1) in urothelial cancers of human bladder: relation to clinicopathological and molecular parameters.

Authors: Cristina Kalogris, Sara Caprodossi, Consuelo Amantini, Federica Lambertucci, Massimo Nabissi, Maria Beatrice Morelli, Valerio Farfariello, Alessandra Filosa, Maria Cristina Emiliozzi, Gabriele Mammana, Giorgio Santoni

Journal, date & volume: Histopathology, 2010 Nov , 57, 744-52

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21083604

Abstract
To evaluate the expression of transient receptor potential vanilloid type-1 channel protein (TRPV1) in normal and neoplastic urothelial tissues and to correlate TRPV1 expression with clinicopathological parameters and disease-specific survival.TRPV1 expression was analysed in normal and neoplastic urothelial samples at both mRNA and protein levels by quantitative real time polymerase chain reaction (qPCR) and immunohistochemistry, respectively. TRPV1 downregulation was found in urothelial cancer (UC) specimens, which correlated with tumour progression. Moreover, TRPV1 mRNA levels were associated with clinicopathological parameters to assess the role of TRPV1 downregulation as a negative prognostic factor for survival. Kaplan-Meier survival analysis demonstrated a significantly shorter survival in patients showing TRPV1 mRNA downregulation. Multivariate Cox regression analysis indicated further that TRPV1 mRNA expression retained its significance as an independent risk factor.The progression of UC of human bladder is associated with a marked decrease in TRPV1 expression, with a progressive loss in high-grade muscle invasive UC. Downregulation of TRPV1 mRNA expression may represent an independent negative prognostic factor for bladder cancer patients.