Referenced in: none

Automatically associated channels: Kv10.1

Title: Phosphoinositide-generated second messengers in cardiac signal transduction.

Authors: J H Brown, E A Martinson

Journal, date & volume: Trends Cardiovasc. Med., 1992 Nov-Dec , 2, 209-14

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/21239243

Abstract
Hokin and Hokin were the first to demonstrate that tissue inositol phospholipid (phosphoinositide, PI) turnover was increased by hormone treatment. Twenty years later, Michell published a seminal review in which he suggested a relationship between stimulated inositol phospholipid metabolism and Ca(2+) mobilization. The biochemical link between these two events was subsequently identified by Berridge and colleagues as inositol trisphosphate (InsP(3)), a Ca(2+)-mobilizing ligand that is formed by the breakdown of phosphatidylinositol bisphosphate (PIP(2)). The other product of inositol phospholipid hydrolysis, diacylglycerol, activates a Ca(2+)-sensitive phospholipid-dependent protein kinase, protein kinase C, which has been considered as a potential regulator of cardiac ion channels, inotropic state, and gene expression. This review summarizes our current state of knowledge concerning the formation of phosphoinositide-generated second messengers in cardiac cells and their potential role in mediating functional responses in the myocardium.