Referenced in: none

Automatically associated channels: Kir2.3

Title: Expression of aquaporin-1 in nasopharyngeal cancer tissues.

Authors: Qi Li, Bao Zhang

Journal, date & volume: J Otolaryngol Head Neck Surg, 2010 Oct , 39, 511-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20828513

Abstract
To investigate the expression of aquaporin-1 (AQP1) in nasopharyngeal tumour and nontumour tissues.Thirty nasopharyngeal biopsy samples were collected and examined with both immunohistochemistry and real-time fluorescence quantitative polymerase chain reaction (RT-PCR) to detect the expression level of AQP1 in tissues.Immunohistochemistry data suggested that AQP1 was expressed in both nasopharyngeal tumour and normal tissues, but tumour tissues were stained a lot stronger than nontumour tissues. RT-PCR analysis further confirmed the overexpression of AQP1 in tumour tissues; migrated tumour tissue had even higher expression.The expression level of aquaporin-1 in nasopharyngeal cancer tissue could be involved in tumour migration.