Referenced in: none

Automatically associated channels: Kv11.1

Title: Investigation of 4-piperidinols as novel H3 antagonists.

Authors: James T Anderson, Michael Campbell, Jianmin Wang, Kurt R Brunden, John J Harrington, Alain Stricker-Krongrad, Jianping Song, Chris Doucette, Steven Murphy, Youssef L Bennani

Journal, date & volume: Bioorg. Med. Chem. Lett., 2010 Nov 1 , 20, 6246-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/20833043

Abstract
Compounds containing a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor. The compounds exhibited up to a 60-fold preference for inhibiting the human H(3) receptor over the mouse and showed a low binding affinity for the hERG channel.