Referenced in: none

Automatically associated channels: Kv2.1

Title: Benzodiazepine inhibition of the calcium-calmodulin protein kinase system in brain membrane.

Authors: R J DeLorenzo, S Burdette, J Holderness

Journal, date & volume: Science, 1981 Jul 31 , 213, 546-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/6264605

Abstract
Benzodiazepines inhibit Ca2+-calmodulin-stimulated membrane protein phosphorylation. The effects of the benzodiazepines on protein phosphorylation are stereospecific and produced by membrane-bound benzodiazepine. The potency of benzodiazepine kinase inhibition is correlated with the ability of the benzodiazepines to inhibit electric shock-induced convulsions. These findings provide evidence that some of the anticonvulsant and neuronal stabilizing effects of benzodiazepines may be modulated by the Ca2+-calmodulin protein kinase system and indicate that this calmodulin-kinase system represents an identifiable benzodiazepine receptor in brain that is distinquishable by several criteria from the previously described high affinity benzodiazepine receptor.