Referenced in: none

Automatically associated channels: Kir2.3

Title: Resolution of the stereoisomers of baclofen by high performance liquid chromatography.

Authors: R P Weatherby, R D Allan, G A Johnston

Journal, date & volume: J. Neurosci. Methods, 1984 Jan , 10, 23-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/6328130

Abstract
The GABA analogue baclofen [3-(p-chlorophenyl)-4-aminobutanoic acid] has stereospecific actions on the peripheral and central nervous systems. This paper describes the resolution of tritium-labelled baclofen by high performance liquid chromatography on a reverse-phase C18 column using a chiral mobile phase. The method, which may have general application to certain other GABA analogues, affords optically pure (+)- and (-)-baclofen labelled with tritium to high specific activity suitable for ligand binding and other neurochemical studies.