Referenced in: none

Automatically associated channels: Kir2.3

Title: A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites.

Authors: P Ferrero, A Guidotti, B Conti-Tronconi, E Costa

Journal, date & volume: Neuropharmacology, 1984 Nov , 23, 1359-62

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/6098849

Abstract
An octadecaneuropeptide (ODN) produced by the tryptic digestion of DBI was purified and sequenced and its activity on the Vogel test determined. In vitro ODN displaces 3H-diazepam from specific brain recognition sites and injected intraventricularly in thirsty rats facilitates the onset of behavioral inhibition elicited by punishment. The alpha-amide derivative of ODN is devoid of either action. Evidence is presented suggesting that DBI sequence includes at least two replicas of ODN or one replica of ODN and a fragment with similar if not identical amino acid sequence but identical biological activity.