Referenced in: none

Automatically associated channels: Kir2.3

Title: Reduced kainic acid binding in rat hippocampal formation after limbic kindling.

Authors: D D Savage, J V Nadler, J O McNamara

Journal, date & volume: Brain Res., 1984 Dec 3 , 323, 128-31

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/6098330

Abstract
The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less than in electrode-implanted unstimulated controls. Specific binding in the inner third of the dentate molecular layer was reduced to a lesser degree. These observations demonstrate that kainic acid receptors are down-regulated by kindling stimulation.