Referenced in: none

Automatically associated channels: Kir2.3

Title: The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia.

Authors: A J Cross, T J Crow, I N Ferrier, J A Johnson

Journal, date & volume: Neurobiol. Aging, 1986 Jan-Feb , 7, 3-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2869422

Abstract
The high-affinity binding of thirteen ligands to putative neurotransmitter receptors was studied in temporal cortex of control and Alzheimer-type dementia (ATD) patients. A selective reduction of serotonin S2 receptors was observed in the ATD patients, to 57% of controls with no change in S1 receptors. Of the other ligand binding sites studied, only 3H-flunitrazepam binding was significantly reduced, to 84% of controls. Ligand binding sites which were unchanged in ATD temporal cortex included those labelled by adrenergic, adenosine, histamine, opiate, GABA, benzodiazepine and cholinergic ligands.