Referenced in: none

Automatically associated channels: Kir2.3

Title: Chiral 1,4-benzodiazepin-2-ones: relationship between stereochemistry and pharmacological activity.

Authors: P Salvadori, C Bertucci, E Domenici, G Giannaccini

Journal, date & volume: J Pharm Biomed Anal, 1989 , 7, 1735-42

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/2562315

Abstract
Pure enantiomers of 3-substituted-1,4-benzodiazepin-2-ones, obtained by HPLC resolution on chiral stationary phases, show significant differences in their pharmacological activity. The occurrence of biotransformation during the pharmacological test is monitored using a new chromatographic method. The reliability of the pharmacological activity data is discussed.