Referenced in: none

Automatically associated channels: Kir2.3

Title: Chronic treatment with L-threonine in amyotrophic lateral sclerosis: a pilot study.

Authors: D Testa, T Caraceni, V Fetoni, F Girotti

Journal, date & volume: Clin Neurol Neurosurg, 1992 , 94, 7-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/1353011

Abstract
Thirty patients suffering from amyotrophic lateral sclerosis were included in an open therapeutical trial. They were randomized to receive either L-threonine (Thr), a precursor of the inhibitory amino acid glycine, or vitamin B or carnitine. Thirteen patients (9 patients on Thr and 4 control subjects) completed the 1-year trial. No statistical differences were observed between the treated group and the control patients in the decline of the clinical assessment score. Nevertheless, Thr-treated patients complained less frequently of respiratory failure than the control group despite bulbar involvement being more common in the Thr group at entry.