Referenced in: none

Automatically associated channels: Kv10.1 , Kv6.3

Title: Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences.

Authors: Joanna Napp, Francisco Monje, Walter Stühmer, Luis A Pardo

Journal, date & volume: J. Biol. Chem., 2005 Aug 19 , 280, 29506-12

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15964838

Abstract
N-Linked glycosylation is a common post-translational modification of membrane proteins. Here we report that mature Eag1 potassium channels carry sugar moieties linked to asparagines at positions 388 and 406. Asn-388 seems to undergo only core glycosylation, but complex sugars are bound to Asn-406. Correct complex glycosylation is required for proper trafficking of Eag1 to the plasma membrane but is also crucial for the correct function of channels already inserted in the membrane.