Referenced in: none

Automatically associated channels: ClC4

Title: P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer.

Authors: Paul W Wirtz, Bethan Lang, Francesc Graus, Arn M J M Van Den Maagdenberg, Albert Saiz, Pia A de Koning Gans, Albert Twijnstra, Jan J G M Verschuuren

Journal, date & volume: J. Neuroimmunol., 2005 Jul , 164, 161-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15904978

Abstract
To assess the survival impact of the presence of P/Q-type calcium channel antibodies in patients with small cell lung carcinoma (SCLC), we examined the frequency of the antibodies and Lambert-Eaton myasthenic syndrome (LEMS) in 148 consecutive patients with SCLC, and in 30 patients with paraneoplastic cerebellar degeneration and SCLC, and studied their relation with survival. In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis.