Referenced in: none

Automatically associated channels: Kir2.3

Title: Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry.

Authors: M Marder, H Viola, J A Bacigaluppo, M I Colombo, C Wasowski, C Wolfman, J H Medina, E A Rúveda, A C Paladini

Journal, date & volume: Biochem. Biophys. Res. Commun., 1998 Aug 19 , 249, 481-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9712722

Abstract
Solution phase combinatorial synthesis of flavone derivatives and evaluation of their affinity for the central benzodiazepine receptors is described. The libraries preparation is simple and provides a convenient method for rapid compound generation and screening. Thirty one new compounds were obtained of which the most promising, as high affinity benzodiazepine receptor ligands, were 6-bromo-3'-fluoroflavone; 6,3'-dichloroflavone; 6-bromo-3'-chloroflavone and 6-chloro-3'-bromoflavone.