Referenced in: none

Automatically associated channels: Kv11.1

Title: 1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists.

Authors: Ian T Huscroft, Emma J Carlson, Gary G Chicchi, Marc M Kurtz, Clare London, Piotr Raubo, Alan Wheeldon, Janusz J Kulagowski

Journal, date & volume: Bioorg. Med. Chem. Lett., 2006 Apr 1 , 16, 2008-12

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/16413782

Abstract
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK(1) receptor antagonists. Substitution at the 6-exo-position led to high affinity NK(1) antagonists with a prolonged duration of action in vivo. Incorporation of an alpha-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.