Referenced in: none

Automatically associated channels: Kir2.3

Title: Strong synergism between GABA(A) and glycine receptors on isolated carp third-order neurons.

Authors: P Li, X L Yang

Journal, date & volume: Neuroreport, 1998 Aug 24 , 9, 2875-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9760138

Abstract
A strong synergistic interaction between the bicuculline-sensitive GABA receptor (GABA(A) receptor) and the strychnine-sensitive glycine receptor was observed in third-order neurons acutely isolated from crucian carp retina, with the use of the whole-cell patch-clamp recording technique. In 58 of 153 cells, 10 microM GABA or glycine separately applied to amacrine/ganglion cells failed to induce any responses or only induced small currents (<20 pA), while co-application of these two chemicals resulted in much larger responses (403.05+/-319.98 pA). The current induced by the co-application was mediated by chloride channels, and both GABA(A) and glycine receptors were involved in the potentiation. The underlying mechanisms of this interaction and its possible physiological role are discussed.